Overdosage of cholestyramine resin continues to be claimed within a client taking a hundred and fifty% of the most encouraged every day dosage for a duration of many months. No ill outcomes were noted.

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Occasional calcified materials is observed from the biliary tree, which include calcification on the gallbladder, in individuals to whom cholestyramine resin continues to be offered. However, This can be a manifestation of the liver disease instead of drug connected.

Cholestyramine resin may perhaps interfere With all the pharmacokinetics of drugs that bear enterohepatic circulation. The discontinuance of cholestyramine resin could pose a hazard to health if a most likely toxic drug like digitalis has actually been titrated to some routine maintenance level while the affected person was taking cholestyramine resin.

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When the First dose is very well tolerated, the dose could be increased as required by one dose/day (at regular monthly intervals) with periodic monitoring of serum lipoproteins. If constipation worsens or the specified therapeutic response isn't obtained at a single to six doses/working day, mix therapy or alternate therapy needs to be regarded as. Certain effort and hard work must be manufactured in order to avoid constipation in individuals with symptomatic coronary artery sickness. Constipation affiliated with cholestyramine resin might aggravate hemorrhoids.

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The commonest adverse reaction is constipation. When used to be a cholesterol-lowering agent, predisposing aspects for many complaints of constipation are superior dose and increased age (over sixty yrs old).

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There's a likelihood that prolonged usage of cholestyramine resin, as it is often a chloride form of anion exchange resin, may well create hyperchloremic acidosis.

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